Peptides derived from GSE24.2 for treating diseases caused by oxidative stress and damage to DNA

摘要

The present invention relates to a polypeptide comprising a fragment (SEQ ID NO: 2) of the peptide GSE24.2 (SEQ ID NO: 1) and capable of reducing free radical generation and / or damage to the structure of cellular DNA. Optionally contains a nuclear localization sequence. The present invention also relates to polynucleotides and vectors comprising sequences encoding the polypeptides, and pharmaceutical compositions comprising the polypeptides, polynucleotides and / or vectors. The invention further treats the use of the above polypeptides (eg, diseases caused by increased oxidative stress and / or damage to intracellular DNA (eg, vasodilatory ataxia or congenital keratosis) And / or use of the polypeptide for prevention or use of the polypeptide in tissue engineering and cell culture to improve cell viability).