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Identification of extracellular forms of PTEN that can be used to treat tumors
Identification of extracellular forms of PTEN that can be used to treat tumors
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机译:鉴定可用于治疗肿瘤的PTEN细胞外形式
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摘要
An isolated human phosphatase and tensin homolog long polypeptide (PTEN-long) comprising SEQ ID NO:1, fragments and analogs thereof, nucleic acids encoding such and compositions comprising such are provided. Methods to inhibit angiogenesis in a solid tumor, treat a solid tumor, and inhibit growth of a solid tumor using PTEN-long, fragments and analogs thereof, are provided.
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机译:提供了包含SEQ ID NO:1的分离的人磷酸酶和肌腱蛋白同源长多肽(PTEN-long),其片段和类似物,编码其的核酸以及包含其的组合物。提供了使用长PTEN的片段及其类似物抑制实体瘤中血管生成,治疗实体瘤和抑制实体瘤生长的方法。
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