Products containing extracellular matrix tissue material and osteogenic proteins

摘要

The osteogenic composition comprises extracellular matrix tissue material and an osteogenic protein, preferably BMP-2. The composition uses BMP usefully, is used at relatively low doses, and is retained in native components (such as heparin and / or heparin sulfate) retained in the decellularized extracellular matrix tissue material. Sulfated glycosaminoglycans). Methods for preparing such compositions and the use of the compositions are also described. The compositions and related methods are used to treat diseased or damaged bone tissue.