Formation of N-protected bis 3,6- (4-aminobutyl) -2,5-diketopiperazine via a cyclic α-N-protected active amino ester intermediate

摘要

A method for the synthesis of N-protected 3,6-aminoalkyl-2,5-diketopiperazine is provided. The process involves obtaining a cyclic α-N-protected active amino ester and adding it to a mixture of amine catalysts in an organic solvent.