Novel process for the preparation of N- (4-nitro-2-sulfamoyl-phenyl) -malonamic acid methyl ester and N- (4-amino-2-sulfamoyl-phenyl) -malonamic acid methyl ester

摘要

The present invention relates to a novel process for preparing the compounds N- (4-nitro-2-sulfamoyl-phenyl) -malonamic acid methyl ester and N- (4-amino-2-sulfamoyl-phenyl) -malonamic acid methyl ester Which are also known commercially as cetrovir and are useful compounds for the treatment of hepatitis C, N- (3-{(1R, 2S, 7R, 8S) -3-[(4- Fluorophenyl) methyl] -6-hydroxy-4-oxo-3-azatricyclo [6.2.1.02,7] undec-5-en-5-yl} -1,1-dioxo-1,4-dihydro-1λ6,2 , 4-Benzothiadiazin-7-yl) a key intermediate for the preparation of methanesulfonamide, a novel for the preparation of N- (4-methanesulfonylamino-2-sulfamoyl-phenyl) -malonamic acid methyl ester Intermediate.