Methods and compositions for the treatment and prevention of diseases associated with intestinal injury and tight junction dysfunction

摘要

Methods and compositions for treating and preventing intestinal injury are described. Specifically, intestinal damage, eg, exercise-induced intestinal damage, non-steroidal anti-inflammatory drug (NSAID) -induced or worsened intestinal damage, or exercise-induced, exacerbated intestinal damage And a composition with a delayed release form of glycerophosphate and an enteric coating are described. A therapeutically effective amount of glycerophosphate, especially calcium glycerophosphate, for subjects who exercise regularly, especially for exercise routinely and to treat or prevent skeletal muscle pain caused by exercise Oral or nasal administration to subjects taking NSAIDs reduces intestinal damage induced by exercise, particularly exercise-induced intestinal damage exacerbated by NSAIDs. Also described is a method for improving the integrity of tight junctions in subjects in need thereof. This method involves administering to the subject an effective amount of glycerophosphate, such as calcium glycerophosphate. Also described are methods of treating or preventing diseases associated with tight junction dysfunction, such as inflammatory diseases or cancer.