To facilitate spinal fusion of the vertebrae in the spinal surgery, zinc, vanadium, tungsten, molybdenum, such as niobium, selenium, and manganese compounds, bone material containing insulin pseudo agent, and method thereof . Furthermore, bone tissue kit for promoting fusion of the vertebrae in spinal fusion surgery, including the formulated compositions for easy application in spinal fusion treatment with insulin pseudo agent and a pharmaceutically acceptable carrier I provide. Also provides an implantable device for promoting a spinal fusion, including a prosthetic implant designed to stabilize and promote fusion of the two adjacent vertebrae, the bone tissue contacting surface of the prosthetic implant, Insulin - is coated with a composition comprising a pseudo-agent.
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