Conjugates to protect against diphtheria and / or tetanus

摘要

Sugar conjugate vaccines that use diphtheria toxoid or tetanus toxoid as a carrier protein may confer protection from lethal attack by diphtheria toxin or tetanus toxin. Thus, in addition to protecting the saccharide bound to the carrier from bacteria, the diphtheria and tetanus can be used in addition to the protection of the saccharide bound to the carrier due to the excess of diphtheria toxoid and tetanus toxoid components of current complex combination vaccines. Can defend against. Thus, the antigenic complexity of these vaccines can be reduced without reducing their breadth of protection. Furthermore, removing these excess components creates room in the vaccine to add an immunogen to protect against other pathogens. Although the same effect has not been confirmed with CRM197 carrier, this observation makes this carrier more attractive for conjugate vaccines provided in combination with an infant combination vaccine containing Dt and Tt. [Selection figure] None