Compositions containing cyclic purine dinucleotides with well-defined stereochemistry and methods for their preparation and use

摘要

The object of the present invention is a novel high activity cyclic-di-nucleotide (CDN) immunostimulation that activates DC through a recently discovered cytoplasmic receptor known as STING (interferon gene stimulator) Is to provide an agent. In particular, the CDN of the invention is provided in the form of a composition comprising one or more cyclic purine dinucleotides that induces STING-dependent TBK1 activation, wherein the cyclic purine dinucleotide present in the composition is substantially Pure Rp, Rp or Rp, Sp stereoisomers, particularly substantially pure Rp, Rp, or RpSp CDN thiophosphate diastereomers. [Selection] Figure 1