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TISSUE NONSPECIFIC ALKALINE PHOSPHATASE INHIBITOR AND USE THEREOF FOR TREATING BLOOD VESSEL CALCIFICATION

机译：组织非特异性碱性磷酸酶抑制剂及其在治疗血管钙化中的用途

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摘要

PROBLEM TO BE SOLVED: To provide a compound as a tissue nonspecific alkaline phosphatase inhibitor.SOLUTION: The present description discloses a tissue nonspecific alkaline phosphatase inhibitor. The disclosed compound is used for therapy, prevention or alleviation of blood vessel calcification, artery calcification and other cardiovascular diseases. In one embodiment, the disclosed compound can comprise the following: A) a ring comprising two or more nitrogen atoms; B) an arylsulfonamide; and C) a compound inhibiting tissue nonspecific alkaline phosphatase having an ICof 20 M or less, which comprises one or more aryl phosphonic acid unit or phosphonic acid unit.

机译：解决的问题：提供一种化合物作为组织非特异性碱性磷酸酶抑制剂。解决方案：本说明书公开了一种组织非特异性碱性磷酸酶抑制剂。所公开的化合物用于治疗，预防或减轻血管钙化，动脉钙化和其他心血管疾病。在一个实施方案中，所公开的化合物可包含以下：A）包含两个或更多个氮原子的环; B）芳基磺酰胺; C）IC为20M或更小的抑制组织非特异性碱性磷酸酶的化合物，其包含一个或多个芳基膦酸单元或膦酸单元。

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公开/公告号JP2015232043A

专利类型
公开/公告日2015-12-24

原文格式PDF
申请/专利权人 BURNHAM INST FOR MEDICAL RESEARCH;
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申请/专利号JP20150186387
发明设计人 MILLAN JOSE LUIS;EDUARD SERGIENKO;
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申请日2015-09-24
分类号A61K31/415;A61K31/275;A61K31/4155;A61K31/416;A61K31/4162;A61K31/4184;A61K31/4196;A61K31/422;A61K31/429;A61K31/437;A61K31/4406;A61K31/4439;A61K31/47;A61K31/517;A61K31/519;A61K31/53;A61K31/542;A61K31/55;A61K31/662;A61P3/10;A61P9;A61P9/14;A61P13/12;A61P43;C07D213/76;C07D215/38;C07D231/14;C07D231/20;C07D231/38;C07D231/54;C07D231/56;C07D235/26;C07D249/08;C07D249/12;C07D249/14;C07D401/12;C07D403/12;C07D405/12;C07D409/04;C07D409/12;C07D413/12;C07D471/04;C07D487/04;C07D487/14;C07D491/052;C07D495/22;C07D513/04;C07D403/04;
国家 JP
入库时间 2022-08-21 14:41:47

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