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Etomidate analogs that do not inhibit corticosteroid synthesis

机译:依托咪酯类似物不抑制皮质类固醇合成

摘要

The invention is directed to compounds according to formula (I): where R1 is L1C(O)OT or L1C(O)OL2C(O)OT; R2 is a substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl, or R1; n is an integer from 0 to 5; each R3 is independently halogen or R2; R4 and R5 are independently H, halogen, CN or CF3; L1 and L2 are each independently a bond, a substituted or unsubstituted C1-C10 alkylene, C2-C10 alkenylene, or C2-C10 alkynylene; and T is H, a substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl, nitrophenol, or cyclopropyl. The invention is also directed to a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, and to methods for providing anesthesia in mammals by administering such a pharmaceutical composition.
机译:本发明涉及根据式(I)的化合物:其中R1是L1C(O)OT或L1C(O)OL2C(O)OT; R2为取代或未取代的C1-C10烷基,C2-C10烯基或C2-C10炔基或R1; n是0至5的整数;每个R 3独立地为卤素或R 2; R4和R5独立地是H,卤素,CN或CF3; L1和L2各自独立地为键,取代或未取代的C1-C10亚烷基,C2-C10亚烯基或C2-C10亚炔基; T是H,取代或未取代的C1-C10烷基,C2-C10烯基或C2-C10炔基,硝基苯酚或环丙基。本发明还涉及包含式(I)的化合物和药学上可接受的载体的药物组合物,并且涉及通过施用这种药物组合物在哺乳动物中提供麻醉的方法。

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