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Novel piperidino-dihydrothienopyrimidine sulfoxide and its use to treat COPD and asthma

机译:新型哌啶子基-二氢噻吩并嘧啶亚砜及其在治疗COPD和哮喘中的应用

摘要

The invention relates to novel piperidino-dihydrothienopyrimidine sulfoxides of formula I, wherein Ring A is a 6-membered aromatic ring which may optionally comprise one or two nitrogen atoms and wherein R is Cl and wherein R may be located either in the para-, meta- or ortho-position of Ring A, wherein S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.
机译:本发明涉及式I的新的哌啶子基-二氢噻吩并嘧啶亚砜,其中环A为可任选包含一个或两个氮原子的6-元芳族环,且其中R为Cl且其中R可位于对位,间位A环的邻位,其中S *是代表手性中心的硫原子,及其所有药学上可接受的盐,对映体和外消旋体,水合物和溶剂化物,以及这些化合物在治疗炎症性或过敏性疾病中的用途呼吸道疾病,例如COPD或哮喘。

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