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A method for measuring the action of the liver of an organism by quantitatively measuring the metabolism of the substrate

机译:通过定量测量底物代谢来测量生物体肝脏作用的方法

摘要

A method for determining the liver performance of a living organism, in particular a human, comprising administering at least one 13C labelled substrate, which is converted by the liver by releasing at least one 13C labelled metabolization product, and determining the amount of the at least one 13C labelled metabolization product in the exhalation air over a definite time interval by the means of at least one measuring device with at least one evaluation unit is disclosed. Using this method, it is possible to describe the measured initial increase of the amount of the at least one 13C labelled metabolization product in the exhalation air using a differential equation of first order and to determine a value Amax (DOBmax) and a time constant tau of the increase of the amount of 13C labelled metabolization product from the solution of the differential equation of first order.
机译:一种确定活生物体,特别是人类的肝功能的方法,包括施用至少一种13C标记的底物,该底物通过释放至少一种13C标记的代谢产物而被肝脏转化,并确定至少一种13C标记的底物的量。公开了通过至少一个具有至少一个评估单元的测量装置在一定时间间隔内在呼出空气中的一种13 C标记的代谢产物。使用该方法,可以使用一阶微分方程描述呼出空气中至少一种13 C标记的代谢产物的测量初始增加量,并确定值Amax(DOBmax)和时间常数tau从一阶微分方程的解中,13C标记的代谢产物的量增加。

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