METHODS TO DISTINGUISH WALDENSTROM'S MACROGLOBULINEMIA FROM IGM MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE

摘要

Diagnostic assays for discriminating Waldenstrom's Macroglobulinemia from IgM monoclonal gammopathy of undetermined significance are provided. The method comprises obtaining a biological sample from a subject in need thereof, performing an allele-specific polymerase chain reaction assay to determine in the biological sample a level of a transcript comprising a mutation at position 38182641 in chromosome 3p22.2, and providing a report indicating whether delta CT value of the biological sample is less than a reference value, wherein the subject has Waldenstrom's Macroglobulinemia if the delta CT value is less than the reference value.