SUPRAMOLECULAR COMPLEXES OF POLYANIONIC POLYMERS AND SPERMIDINE IN TISSUE MAINTENANCE AND REPAIR

摘要

Supramolecular complexes are formed by polyanionic polymers and spermidine having a ratio of anionic equivalents ranging from 10¹:1 to 10⁷:1 eq/eq, more preferably from 10²:1 to 10⁴:1 eq/eq, whose components are linked by non-covalent, ionic interactions. The supramolecular complexes are exhibit high potency in eliciting fibroblast proliferation. Disclosed are medicinal/cosmetic compositions containing the supramolecular complexes for the trophism, maintenance, regeneration, and repair of connective tissues and mucosae in damaged or senescent conditions.