METHOD FOR DETERMINING IN VIVO TISSUE BIOMARKER CHARACTERISTICS USING MULTIPARAMETER MRI MATRIX CREATION AND BIG DATA ANALYTICS

摘要

A method for determining MRI biomarkers for in vivo issue includes the steps of obtaining raw data concerning the in vivo tissue from a MRI machine; processing the raw data to obtain parameter maps; when applicable, registering images such that the exact same tissue at serial points can be analyzed; applying a grid over a region of interest to create sub-regions of interest (SROIs); inserting parameter measures for each SROI into a spreadsheet program to create a large 3D data matrix; applying standard big-data analytics including data mining and statistics of matrix measures to find patterns of measurement values or measure changes (which may include established biomarkers). A medical imaging software program is used to obtain the parameter maps from the raw data and place multiple grids over the SROIs. 3D matrix measures may be data mined and analyzed using standard big-data analytics.