The present invention provides CSF protein-based biomarkers and biomarker combinations that are useful in diagnosing dementia or a dementia related neurological disorder a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as Alzheimer's dementia, non-Alzheimer's dementia, as Progressive supranuclear palsy (PSP), non-PSP dementia or normal. In some aspects, the invention relates to methods useful for diagnosing, classifying, and profiling dementia or a dementia related neurological disorder a patient.
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