首页>
外国专利>
TREATMENT OF DRUG ABUSE BY PREVENTING GAPDH NITROSYLATION
TREATMENT OF DRUG ABUSE BY PREVENTING GAPDH NITROSYLATION
展开▼
机译:预防GAPDH亚硝化治疗药物滥用
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to the field of drug abuse. More specifically, the present invention provides methods and compositions for treating drug abuse by preventing GAPDH nitrosylation. In one specific embodiment, a method for preventing the stimulant and neurotoxic effects of cocaine comprises the step of administering a compound that prevents the nitrosylation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) by nitric oxide (NO). In another embodiment, a method for preventing the stimulant and neurotoxic effects of cocaine comprises the step of administering a compound that prevents the binding of GAPDH to Siah.
展开▼