According to an aspect, a system includes transportation module configured to generate a transportation plan for packages scheduled to be routed through a regional logistics network such that the transportation plan minimizes transportation costs. The transportation module may include a pickup plan module, a depot-to-depot plan module, and a delivery plan module. The pickup plan module may be configured to compute a pickup transportation plan for packages to be picked-up from the customers in the customer area of an origin depot. The depot-to-depot plan module may be configured to compute a depot-to-depot transportation plan for packages transferred between the origin depot and a destination depot. The delivery plan module may be configured to compute a delivery transportation plan for delivering packages from the destination depot to the customers within the customer area of the destination depot.
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