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Suppression of Cytokine Release and Cytokine Storm

机译:抑制细胞因子释放和细胞因子风暴

摘要

The present invention includes methods and compositions for ameliorating symptoms or treating one or more adverse reactions triggered by infectious diseases or disease conditions that trigger a widespread release of cytokines in a subject comprising the steps of: identifying the subject in need of amelioration of symptoms or treatment of the infectious diseases or disease conditions that trigger a widespread release of cytokines; and administering one or more pharmaceutical compositions comprising a therapeutically effective amount of a curcumin extract, curcuminoids or synthetic curcumin (S-curcumin) and derivatives thereof, or empty liposomes, dissolved or dispersed in a suitable aqueous or non-aqueous medium sufficient to reduce the level of cytokines in the host.
机译:本发明包括用于减轻症状或治疗由感染性疾病或疾病状况引发的一种或多种不良反应的方法和组合物,所述不良反应触发了细胞因子在受试者中的广泛释放,包括以下步骤:识别需要减轻症状或治疗的受试者引发细胞因子广泛释放的传染病或疾病状况;以及施用一种或多种药物组合物,其包含治疗或有效量的姜黄素提取物,姜黄素或合成姜黄素(S-curcumin)及其衍生物,或空脂质体,溶解或分散在足以减少水肿的适当水性或非水性介质中宿主细胞因子水平。

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