DETERMINATION OF PHYSIOLOGICAL PARAMETERS OF TISSUE FROM DYNAMIC CONTRAST-ENHANCED MR DATA

摘要

A method of determining microvascular architecture is disclosed. Dynamic contrast-enhanced magnetic resonance data acquired from a contrast agent administered to at least a part of a subject to be examined. From the dynamic contrast-enhanced magnetic resonance data a leakage parameter (k_ep) and a dispersion parameter (κ) are computed. Effects of both convective dispersion and extravasation kinetics of contrast agent are taken into account.