USING PLEXIN-A4 AS A BIOMARKER AND THERAPEUTIC TARGET FOR ALZHEIMER'S DISEASE

摘要

The present disclosure provides methods, assays and systems for detecting an increased risk for Alzheimer's disease (AD) in a subject by identifying at least one nucleic acid polymorphism described herein in a biological sample from the subject. Levels of the genes associated with the nucleic acid polymorphism described herein are also determined for detection of higher risk for AD. Disclosure further provides methods for treating AD by administering to a subject in need thereof a TS1 PLXNA4 inhibitory agent.