首页>
外国专利>
PREPARATION OF BONE-SEEKING SUPERPARAMAGNETIC IRON NANOPARTICLES AS CONTRAST AGENTS AND METHODS FOR USING THE SAME
PREPARATION OF BONE-SEEKING SUPERPARAMAGNETIC IRON NANOPARTICLES AS CONTRAST AGENTS AND METHODS FOR USING THE SAME
展开▼
机译:求骨超顺磁性铁纳米粒子作为造影剂及其使用方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
Described herein are compositions having a nanoparticle that is conjugated to at least one bone targeting moiety, wherein the bone targeting moiety is bonded to the nanoparticle by a linker, wherein the nanoparticle contains iron, and wherein the compositions are neutral or pharmaceutically acceptable salts or esters. Also described herein are methods of making these compositions. In one aspect, the nanoparticles serve as contrast agents for magnetic resonance imaging of bone metabolism. The compounds, compositions, and methods described herein can be used in a number of therapeutic applications including diagnosing or monitoring fracture and/or the progress of conditions associated with bone loss, which include, but are not limited to, osteoporosis, Paget's disease, osteolytic tumors, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, osteoarthritis, osteopenia, and hypercalcemia.
展开▼