FORMULATIONS CONTAINING POLY (0-2 HYDROXYETHYL) STARCH FOR INCREASING THE OXYGEN-CONTENT, STABILITY AND SHELF LIFE OF AN ORGAN AND TISSUE PRESERVATION SOLUTION

摘要

Organ and tissue preservation solutions having improved formulations. The improved solutions are comprised of two separate solutions. The first solution, is comprised of one or more salts, water, dissolved oxygen, Poly (0-2-hydroxyethyl) starch, lactobionic acid, adenosine, raffinose and allopurinol and said first solution has a pH of at least 7.0;, preferably from about 7.3 to about 8.2; and a second solution comprised of water, and reduce glutathione at a pH of below 7.0, preferably from about 3 to 6 wherein oxygen present in the solution is removed. The two formulations are then mixed together at the point of use resulting in the organ and tissue preservation solution having improved stability and that contains oxygen to prevent ischemia in the preserved organs. The present invention is also comprised of kits that contain the two formulations.