首页> 外国专利> SENSITIZATION OF CANCER CELLS TO APOPTOSIS INDUCTION BY FLAVAGLINES AND 5-HYDROXY-FLAVONES

SENSITIZATION OF CANCER CELLS TO APOPTOSIS INDUCTION BY FLAVAGLINES AND 5-HYDROXY-FLAVONES

机译:黄酮和5-羟基黄酮对癌细胞诱导凋亡诱导的敏感性

摘要

The present invention relates to a combined preparation for simultaneous, separate or sequential use comprising at least one flavagline or a pharmaceutically acceptable salt thereof; and/or at least one 5-hydroxy-flavone or a pharmaceutically acceptable salt thereof; and at least one agent activating the intrinsic pathway of apoptosis for use in the treatment of cancer. The N present invention further relates to a medicament comprising the combined preparation of the present invention, as well as to a kit comprising the combined preparation or a medicament according to the present invention and a means for administering at least one of its components. Moreover, the present invention relates to a method of inhibiting a cancer cell, comprising contacting said cancer cell with the combined preparation of the present invention, and thereby inhibiting said cancer cell.
机译:本发明涉及用于同时,分开或相继使用的组合制剂,其包含至少一种黄f碱或其药学上可接受的盐。和/或至少一种5-羟基黄酮或其药学上可接受的盐;至少一种激活细胞凋亡内在途径的试剂用于治疗癌症。本发明还涉及包含本发明的组合制剂的药物,以及涉及包含本发明的组合制剂或药物的试剂盒以及用于施用其至少一种组分的手段。此外,本发明涉及抑制癌细胞的方法,该方法包括使所述癌细胞与本发明的组合制剂接触,从而抑制所述癌细胞。

著录项

  • 公开/公告号US2016158189A1

    专利类型

  • 公开/公告日2016-06-09

    原文格式PDF

  • 申请/专利权人 DEUTSCHES KREBSFORSCHUNGSZENTRUM;

    申请/专利号US201414905442

  • 发明设计人 PETER KRAMMER;MIN LI-WEBER;

    申请日2014-07-15

  • 分类号A61K31/343;A61K31/352;

  • 国家 US

  • 入库时间 2022-08-21 14:34:02

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