Peptides for the Treatment of Immune Reconstitution Inflammatory Syndrome (IRIS) and Related Diseases

摘要

A method of treatment of Immune Reconstitution Inflammatory Syndrome (IRIS) in a patient is disclosed. The method comprises preparing a composition comprising a D peptide and a pharmaceutically acceptable carrier.,said D peptide further comprises the general structure: A-B-C-D-E-F-G-H in which:A is Ala, or absent,B is Ser, Thr or absent,C is Ser, Thr or absent,D is Ser, Thr, Asn, Glu, Arg, Ile, Leu,E is Ser, Thr, Asp, Asn,F is Thr, Ser, Asn, Arg, Gln, Lys, Trp,G is Tyr, andH is Thr, Ser, Arg, Gly, andAll amino acids are the D stereoisomeric configuration. The composition is administered to the patient in a therapeutically effective dose and the composition acts to treat IRIS in the patient.