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Crystal Structure of Staphylococcus Aureus Clumping Factor A in Complex with Fibrinogen Derived Peptide and Uses Thereof

机译：金黄色葡萄球菌聚集因子A与纤维蛋白原衍生肽复合物的晶体结构及其用途

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摘要

The present invention discloses crystal structure of Staphylococcus aureus Clumping factor A (ClfA) in complex with fibrinogen (Fg) derived peptide. Also, the present invention also discloses the use of this structure in the design of ClfA targeted vaccines and therapeutic agents (including monoclonal antibodies). In addition, the present invention discloses isolated and purified engineered Staphylococcus clumping factor A protein (ClfA) with a stabilized, closed conformation and immunogenic compositions thereof including methods of treating a Staphylococcus infection in an individual.

机译：本发明公开了与纤维蛋白原（Fg）衍生的肽复合的金黄色葡萄球菌聚集因子A（ClfA）的晶体结构。而且，本发明还公开了该结构在设计靶向ClfA的疫苗和治疗剂（包括单克隆抗体）中的用途。另外，本发明公开了具有稳定的闭合构象的分离纯化的工程化的葡萄球菌聚集因子A蛋白（ClfA）及其免疫原性组合物，包括治疗~~葡萄球菌感染的方法。在个人中。~~ ~~展开▼~~

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公开/公告号US2016194377A1

专利类型

公开/公告日2016-07-07

原文格式PDF

申请/专利权人 THE TEXAS A&M UNIVERSITY SYSTEM;
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申请/专利号US201615077323

发明设计人 MAGNUS HOOK;YA-PING KO;EMANUEL SMEDS;VANNAKAMBADI K. GANESH;
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申请日2016-03-22

分类号C07K14/75;C07K14/31;C07K16/36;G01N33/68;C07K16/12;

国家 US

入库时间 2022-08-21 14:33:13

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