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Early detection of hepatocellular carcinoma in high risk populations using MALDI-TOF Mass Spectrometry
Early detection of hepatocellular carcinoma in high risk populations using MALDI-TOF Mass Spectrometry
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机译:MALDI-TOF质谱法早期发现高危人群的肝细胞癌
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摘要
Hepatocellular carcinoma (HCC) is detected in a patient with liver disease. Mass spectrometry data from a blood-based sample from the patient is compared to a reference set of mass-spectrometry data from a multitude of other patients with liver disease, including patients with and without HCC, in a general purpose computer configured as a classifier. The classifier generates a class label, such as HCC or No HCC, for the test sample. A laboratory system for early detection of HCC in patients with liver disease is also disclosed. Alternative testing strategies using AFP measurement and a reference set for classification in the form of class-labeled mass spectral data from blood-based samples of lung cancer patients are also described, including multi-stage testing.
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