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Genetically modified rat models for severe combined immunodeficiency (SCID)
Genetically modified rat models for severe combined immunodeficiency (SCID)
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机译:转基因大鼠模型的严重联合免疫缺陷症(SCID)
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摘要
This invention relates to the engineering of animal cells, preferably mammalian, more preferably rat, that are deficient due to the disruption of tumor suppressor gene(s) or gene product(s). In another aspect, the invention relates to genetically modified rats, as well as the descendants and ancestors of such animals, which are animal models of human cancer and methods of their use.
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