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Amino acid dehydrogenase, and process for producing L-amino acid, 2-oxo acid or D-amino acid

机译:氨基酸脱氢酶以及生产L-氨基酸,2-氧代酸或D-氨基酸的方法

摘要

The present invention relates to a novel amino acid dehydrogenase, DNA encoding the enzyme, and a transformant having the DNA introduced therein. The present invention also relates to a process for producing an L-amino acid, 2-oxo acid or D-amino acid, which includes allowing the amino acid dehydrogenase or a microorganism or transformant capable of producing the enzyme to act on a substrate compound. The amino acid dehydrogenase has good reactivity even with an amino acid or a 2-oxo acid each having a bulky side chain such as an aromatic-ring-containing group, which acids are poorly reactive with conventional amino acid dehydrogenases. The amino acid dehydrogenase enables the inexpensive and highly efficient production of a useful optically active amino acid.
机译:本发明涉及一种新颖的氨基酸脱氢酶,编码该酶的DNA以及其中引入了DNA的转化体。本发明还涉及产生L-氨基酸,2-氧代酸或D-氨基酸的方法,其包括使氨基酸脱氢酶或能够产生该酶的微生物或转化体作用于底物化合物。氨基酸脱氢酶即使与具有庞大的侧链的氨基酸或2-氧代酸(例如含芳香环的基团)具有良好的反应性,该酸与常规氨基酸脱氢酶的反应性差。氨基酸脱氢酶能够廉价且高效地生产有用的光学活性氨基酸。

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