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Gramicidin a mutants that function as antibiotics with improved solubility and reduced toxicity
Gramicidin a mutants that function as antibiotics with improved solubility and reduced toxicity
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机译:Gramicidin a突变体,具有改善溶解性和降低毒性的抗生素功能
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摘要
Described herein are antimicrobial peptides for use in pharmaceutical antibiotic compositions and methods of use thereof. These antimicrobial peptides are Gramicidin A (gA) peptide analogs that, in addition to having potent anti-microbial activity, have greatly increased solubility and significantly reduced toxicity in comparison to the wild-type Gramicidin A peptide.
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