Use of a fluorinated polymer as a contrast agent in solid state 19F magnetic resonance imaging (MRI), scaffold comprising said polymer and use thereof

摘要

A method of using a fluorinated polymer having a glass transition temperature below 40 C as a contrast agent in ¹⁹F magnetic resonance imaging (MRI) of a solid object, said solid object comprising said contrast agent. The invention relates to a solid object comprising a structural component and an imaging component, wherein the imaging component is at least one fluorinated polymer. The invention relates to a method for ¹⁹F MRI in solid state using a contrast agent comprising a fluorinated polymer as well as a method for in vivo visualizing a scaffold. It further relates to a method for in vivo monitoring the degradation of a solid object in time, wherein the degradation is monitored in time by using ¹⁹F MRI to visualize the solid object, and wherein the amount of degradation of the solid object is determined based on the decrease in the visibility of the amount of ¹⁹F.