首页>
外国专利>
Method of cloning a lambda light chain variable domain using a human lambda light chain mouse
Method of cloning a lambda light chain variable domain using a human lambda light chain mouse
展开▼
机译:使用人λ轻链小鼠克隆λ轻链可变域的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
Genetically modified mice are provided that express human λ variable (hVλ) sequences, including mice that express hVλ sequences from an endogenous mouse λ light chain locus, mice that express hVλ sequences from an endogenous mouse κ light chain locus, and mice that express hVλ sequences from a transgene or an episome wherein the hVλ sequence is linked to a mouse constant sequence. Mice are provided that are a source of somatically mutated human λ variable sequences useful for making antigen-binding proteins. Compositions and methods for making antigen-binding proteins that comprise human λ variable sequences, including human antibodies, are provided.
展开▼