formulation of microparticles for administration of anti-infective molecule pulmonary drugs for the treatment of infectious diseases

摘要

formulation of microparticles for the administration of anti-infective molecule pulmonary drugs for the treatment of infectious diseases. The present invention relates to an inhalable biodegradable microparticle formulation containing a compound of formula I obtained by fermentation of a microorganism of the streptomyces species (pm626271 / mtcc5447) as described in PCT application publication wo2011027290, and a biodegradable lipid for drug delivery, wherein the ratio of drug (compound of formula i) to lipids is 1:15 - 1:25. The present invention also relates to the process for preparing the formulation and method of treating pulmonary tuberculosis, multidrug resistant tuberculosis (mdrtb), methicillin resistant staphylococcus aureus (mrsa), and staphylococcus pneumonias staphylococcus aureis (mssa) administration. of pneumonia therapeutically effective amount of the formulation to a mammal in need thereof. The present invention further relates to a method of delivering the microparticle formulation to a method of need thereof, wherein the formulation is administered by inhalation or intratracheal instillation for pulmonary delivery.