method for inducing an immune response in a subject against a parasite antigen that causes malaria

摘要

method for inducing an immune response in a subject against a parasite antigen that causes malaria. The invention provides methods for inducing an immune response in a subject against a malaria parasite antigen, preferably e.g. falciparum, the method comprising: (i) administering to a subject an initiator composition comprising adjuvant protein antigen comprising circumsporozoite protein (cs) or immunogenic part thereof from a malaria parasite; (ii) administering to the subject a first booster composition comprising a recombinant adenovirus vector comprising nucleic acid encoding the cs protein or immunogenic part thereof from a malaria-causing parasite; and (iii) administering to the subject a second booster composition comprising a recombinant adenovirus vector comprising nucleic acid encoding the cs protein or immunogenic part thereof from a malaria-causing parasite, wherein both the first The booster comprises a serotype 35 (ad35) recombinant adenovirus vector whereas the second booster comprises an ad26 recombinant adenovirus, or wherein the first booster comprises an ad26 recombinant adenovirus vector and the second booster comprises a recombinant ad35 adenovirus.