silk fibroin microneedles and methods for making them

摘要

silk fibroin-based microneedles and methods for making them. The present invention relates to a microneedle or microneedle device including a microneedle body extending from a base to a penetration tip formed from a silk fibroin-based material which is easy to use. manufacture and highly biocompatible. The microneedle device may include one or more microneedles mounted on a substrate. Silk fibroin may include active agents to be transported into or through biological barriers such as skin, tissue and cell membranes. Silk fibroin microneedles may be fully or partially biodegradable and / or bioerodible. Silk fibroin is highly stable, provides storage at room temperature and is implantable. The silk fibroin structure can be modulated to control the rate of active agent delivery.