Method for production of recombinant human factor VIII, recombinant human factor VIII, pharmaceutical product, the use of recombinant human factor VIII, a method for the treatment of diseases related to decreased, inactivation or absence of factor VIII, the use of endoprotease spc6 and / or pace4 Oh, and / or pacesol and proteolytic processing of recombinant human factor VIII.

摘要

Summary method for production of recombinant human factor VIII to the present invention has for object methods for the production of recombinant human factor VIII, which employ specific Endoproteases, ensuring the complete proteolytic processing of this factor during its biosynthesis. Consequently, avoiding the additional steps of purification.Objects of the present invention is recombinant human factor VIII obtained by such methods, pharmaceutical compositions, uses and methods of treatment related.