Pharmaceutical preparation containing carvacrol with B - cyclodextrin with property, anti inflammatory and anti pain

摘要

Pharmaceutical preparation containing carvacrol with B - cyclodextrin with property ainti inflammatory and anti pain. The present invention patent refers to a new formulation for use of carvacrol, the complex inclusion of carvacrol (B - cyclodextrin.This is a formulation, the active ingredient, carvacrol, complexed to the B - cyclodextrin shows, in low doses, antiflamatoria properties and anti pain in model of skeletal muscle injury, reducing the risk to the patient and the costs of treatment.Although this is a clinical condition important pharmacological treatment for muscular inflammation still remains associated with many adverse effects, it involves high costs and often unsatisfactory, resulting in functional impairments and labor.Thus, the inclusion complex of carvacrol with B - cyclodextrin, is a model of utlidade promising, since the complexation ensures the effect ainti inflammatory and antinociceptivo of carvacrol, even under the use of low doses, when administered orally.This pharmaceutical formulation of inclusion complex was tested in tested doses of 2.5 mg / 10 mg / kg and 20 mg / kg of carvacol. Results were obtained which demonstrate the therapeutic advantage of utlilizau00e7u00e3o compound in the form of inclusion complex.