Pharmaceutical composition with analgesic activity on the basis of a toxin from spider, fusion protein, expression vector of the toxin and uses

摘要

Pharmaceutical composition with analgesic activity on the basis of a toxin from spider, fusion protein, expression vector of the toxin and uses, the present invention relates to a composition with analgesic activity comprising the toxin pntx4 (5, 5) (SEQ ID NO 1) of the spider Phoneutria nigr Iventer more pharmacologically acceptable excipients and their use in the treatment of various types of pain.More precisely, its use in analgesia via central. This composition was shown to be highly effective in the treatment of pain in models of inflammatory and neuropathic nociception in acute, chronic.The invention is also the expression vector pet32a - C (+) TX4 (SEQ ID No. 3) and the fusion protein (SEQ ID No. 2) expressed by this vector and the use of both in the synthesis of the toxin pntx4 (5, 5) (SEQ ID NO 1) recombinant.