vaccine composition for immunization of an animal against mycoplasma hyopneumoniae infection and vaccine

摘要

"improved mycoplasma hyopneumoniae bacterin vaccine". The invention provides an improved mycoplasma hyopneumoniae bacterin vaccine composition, which advantageously provides immunity against infection after a single administration. The composition comprises an inactivated mycoplasma hyopneumoniae bacterin and an auxiliary mixture which, in combination, provides immunity against mycoplasma hyopneumoniae infection upon single administration, and elicits a mycoplasma hyopneumoniae bacterin-specific immune response and including cell-mediated immunity and immunity. local (iga secretory). in a preferred embodiment, the auxiliary mixture comprises an acrylic acid polymer, more preferably carbopol, and a metabolizable oil mixture such as one or more terpene hydrocarbons, preferably squalene or squalane, and polyoxyethylene polypropylene block copolymer such as as pluronic 32. The vaccine composition may optionally include a preservative, preferably thimerosol and / or edta.