Method and kit for correlating the relative levels of the quantity of at least one of HER-2 or homodu00edmeros of HER-2 in a biological sample from an individual, and method for predicting if an individual with cancer and that is treated with an agent that acts on HER2 is likely to have an event s. Ignificante.

摘要

Methods are provided for determining or otherwise assessing the response of a patient to treatment, in particular, to cancer treatment. The methods include the analysis of samples for the presence or the absence of HER2 markers alone or in conjunction with other biomarkers, such as HER3 markers. In certain examples, the probable time to progression can be determined by first determining HER2 positive patients and then further stratifying by using the presence or the absence of a second biomarker (e.g, HER3 markers). In addition, the data can be used to track a patient's response to a treatment regimen, assessing the expected success of treating a patient using a particular regiment, determining the effects of a treatment regiment or for categorizing a patient in order to create a homogenous group for a clinical trial.