BIOCONJUDGES OF SYNTHETIC APPELINATION POLICEPTS

摘要

The invention provides a bioconjugate comprising a synthetic polypeptide of Formula I ': SPACE FOR FORMULA I' or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8 , X9, X10, X11, X12, and X13 are defined herein and a half-life span fraction where the peptide and half-life span fraction are covalently linked or fused, optionally through a linker. Polypeptides are APJ receptor agonists. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.