Polychlorinated dibenzo-p-dioxins for the treatment of heart disease

摘要

The invention provides a cyclic polypeptide of Formula I '(SEQ ID NO: 1): SPACE FOR FORMULA I or an amide, an ester or salt thereof, or a bioconjugate thereof, wherein X1, X3, X4, X7 , X8, X9, X10, X11, X12 and X13 are defined herein. Polypeptides are agonists of the APJ receptor. The invention also relates to a method for the manufacture of the polypeptides of the invention or bioconjugates thereof, and their therapeutic uses such as the treatment or prevention of decompensated acute heart failure (IDAC),Chronic heart failure, pulmonary hypertension, myocardial fibrosis, Brugada syndrome, ventricular acceleration, myocardial infarction, hypertension, shock, ischemic cardiovascular disease, heart disease, myocardial infarction, arrhythmia, arrhythmia, no water, diabetes (including gestational diabetes)Obesity, peripheral arterial disease, cerebrovascular accident, transient ischemia, traumatic brain injury, amebic transverse sclerosis, burns (including sunburn) and chlamydia. The present invention also provides a combination of active pharmaceutical preparations and pharmaceutical ingredients.