A METHOD FOR THE ACTIVITY OF ALPHA-KAP_-17-11B(4-DIMETHYLAMINO)PHENYL-21-BASE-19-_P-P-P-E-GAMMA a-49-Delta_-E-20-Delta_AND MEDIA-KEY

摘要

The present invention relates to a known synthetic method, alpha-kappa-e_-17-11B (4-dimethylamino) phenyl] 21-yl-19-_rho-p-e-y a-49-delta-e_-e_-20-delta_ (later human cdbeta-4124). (1) [1,2-3-alpha_theta_delta__100 million (acid) - __rho-5 (10), 9 (11) - delta_e_-17 - the only type (2). The EU CD beta 4124 belongs to the anti hormone group.The method according to the present invention is as follows: (i) epoxy resins forming double bonds at position 5 (10) [1,2-3-alpha_theta_delta_100 million (acid) - rho-5 (10), 9 (11) - _-17-_. Formula (II); (ii) 5,10 alpha-17-3.3-[1] is obtained by adding the epsilon pi_zeta_formed at the site of oxidation cyanidation.Alpha959595959595959595959595965;lambda_) - 17-hydroxy 5A zeolite959595nd2-alpha9595959595959595959595Grignard reagent The position of hydroxyl groups formed in the Teutsch reaction of CuCl (A. V) methylsilylation is 5 - 11 [4 - (dimethylamino) phenyl] 1 - 3;2-alpha95953;9595959595959595959595963;_ VI) Reaction, 4-(11B) (two methylamino) phenyl] - [1, 2-3 - alpha, theta, alpha, Delta, [1] (5),(trimethylmethylsilsilane-17-bis-(acid) - 5-9-in-17B9595Alpha__.7) 5,(trimethylmethylsilyl-17-bis-(acid) -5-9-in-situ formation of methyl Grignard reagent at-17B____ - kappa alpha_______96 (eight)