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FREMGANGSMÅDE TIL SCREENING AF ET BIOLOGISK MÅL FOR SVAGE INTERAKTIONER VED ANVENDELSE AF SVAG AFFINITETSKROMATOGRAFI
FREMGANGSMÅDE TIL SCREENING AF ET BIOLOGISK MÅL FOR SVAGE INTERAKTIONER VED ANVENDELSE AF SVAG AFFINITETSKROMATOGRAFI
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机译:使用弱亲和力色谱法筛选弱相互作用的生物靶标的程序
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摘要
The present invention relates to a method of screening a biological target for transient weak interactions between the target and a library of ligands. The method includes the provision of a composition comprising a biological target and the provision of a plurality of stationary phases from such a composition. A plurality of ligand compositions is transported to the stationary phases to establish contacts between the ligands and the biological targets. Zonal retardation information are collected for each ligand, downstream of the stationary phases in order to select ligands with dissociation constants (Kd) in the range of 0.01 to 10 mM, exhibiting weak affinity to the target.
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