Sequence symmetric modified bispecific IgG4 antibodies.

摘要

The present disclosure relates to a symmetric bispecific antibody of the class IgG4 comprising two heavy chains which each comprise a variable domain, CH1 domain and a hinge region, wherein in each heavy chain the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, is substituted with another amino acid; and the cysteine at position 239 and/or the cysteine at position 242, numbered according to the Kabat numbering system, is substituted with another amino acid, wherein the constant region sequence of each heavy chain is similar or identical and the variable region in each heavy chain is different, formulations comprising the same, the use of each of the above in treatment and processes for preparing said antibodies and formulations.