MULTI-DAY PLASTER FOR INTERCUTABLE ROTIGOTIN INTRODUCTION

摘要

The invention relates to a transdermal therapeutic system comprising (a) a protective layer, (b) a layer of a self-adhesive solvent-based matrix containing rotigotine as an active ingredient, and (c) a protective film, where a layer of a self-adhesive matrix is characterized by a coating weight of about 75-400 g / mi includes a reservoir layer containing approximately 9-25 wt.% rotigotine based on the weight of the reservoir layer. In addition, the invention relates to a kit comprising two such transdermal therapeutic systems, as well as to a method for producing such a transdermal therapeutic system. In addition, the invention relates to a transdermal therapeutic system comprising rotigotine as an active ingredient, for use in the treatment of patients suffering from Parkinson's disease, Parkinsonism-plus syndrome, depression, fibromyalgia and restless legs syndrome, and for use in the treatment or prevention loss of dopaminergic neurons or cognitive disorders, by percutaneous administration of rotigotine once or twice a week, where the transdermal therapeutic system includes a protective layer, A solvent-based, self-adhesive matrix containing rotigotine as well as a protective film is intended for transdermally administering therapeutically effective amounts of rotigotine for at least 3 days.