首页> 外国专利> METHOD FOR PRODUCING METHYL {4,6-DIAMINO-2- 1- (2-FLUOROBENZYL) -1H-PYRAZOLO 3,4-b Pyridine-3-IL Pyrimidine-5-IL} Methylcarbammate and its purification for use AS A PHARMACEUTICAL BIOLOGICALLY ACTIVE SUBSTANCE

METHOD FOR PRODUCING METHYL {4,6-DIAMINO-2- 1- (2-FLUOROBENZYL) -1H-PYRAZOLO 3,4-b Pyridine-3-IL Pyrimidine-5-IL} Methylcarbammate and its purification for use AS A PHARMACEUTICAL BIOLOGICALLY ACTIVE SUBSTANCE

机译:制备甲基{4,6-二氨基-2- [1-(2-氟苯)-1H-吡唑并[3,4-b]吡啶-3-IL]嘧啶-5-IL}的方法及其使用的提纯作为药物生物活性物质

摘要

The present invention relates to a method for producing methyl {4,6-diamino-2- [1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridin-3-yl] pyrimidin-5-yl} methyl carbamate of the formula (I ) as well as a method for purifying the starting material of a compound of formula (I) for use as a pharmaceutically active substance, and for purifying methyl {4,6-diamino-2- [1- (2-fluorobenzyl) -1H-pyrazolo [3,4- b] pyridin-3-yl] pyrimidin-5-yl} methyl carbamate sulfinyl dimethane (1: 1), i.e. in this purification method, the compound of formula (II) is isolated as an intermediate stage or obtained as an intermediate stage, if necessary in a mixture.
机译:甲基{4,6-二氨基-2- [1-(2-氟苄基)-1H-吡唑并[3,4-b]吡啶-3-基]嘧啶-5-基}的制备方法式(I)的氨基甲酸甲酯以及纯化用作药物活性物质的式(I)化合物的起始原料和纯化甲基{4,6-二氨基-2- [1- (2-氟苄基)-1H-吡唑并[3,4-b]吡啶-3-基]嘧啶-5-基}氨基甲酸酯亚砜基甲烷(1:1),即在该纯化方法中,为式(II)的化合物)可以作为中间产物分离出来,也可以作为中间产物获得,如果需要的话可以混合使用。

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