COMPOSITIONS FOR CONSERVATION OF ORGANS AND TISSUES WITH IMPROVED SUSTAINABILITY AND STORAGE

摘要

Compositions are proposed for the preservation of organs and tissues with increased stability and shelf life due to the separation of the composition into a first solution, whose pH is at least 7, and a second solution, whose pH is less than 7. The first solution contains components with improved stability in storage conditions at a pH of 7 or higher, and the second solution contains components with improved stability in storage conditions at a pH below 7. The first solution contains water, a balanced salt solution, sugar R, adenosine, orotic acid, malic acid, L-carnitine and insulin. The second solution contains water, an antioxidant such as ascorbic acid, a cellular reductant such as reduced glutathione, L-citrulline, creatine monohydrate, L-carnosine and L-arginine. In the process of using the first and second solutions are mixed, and the final composition is formed, which can be used at pH at a physiological level to preserve the function of a tissue or organ.