INJECTION COMPOSITION WITH CONTROLLED SURVIVAL, CONTAINING A LIQUID MEDIA WITH A HIGH VISCOSITY

摘要

Disclosed is a carrier preparation for the controlled release of injectable drugs. The formulation contains a pharmaceutical active agent, a highly viscous liquid carrier material such as sucrose acetate isobutyrate, a lactic acid based polymer such as poly (lactic acid) (glycolic acid), and an organic solvent that keeps the composition in monophasic form at 25 ° With and pressure of 1 atm. The drug is released when administered in such a way that less than 10% (for example, 2-8%) of the drug is released during the first 5 hours; 10-80% of the drug is released over a period of 5 hours to 7 days after administration and 10-40% of the drug is gradually released over a period of 7 to 28 days after the initial administration. The drug may be an anti-schizophrenia agent for injection.